| Pitcher, Club | W | L | IP | H | BB | SO | ERA |
|---|---|---|---|---|---|---|---|
| Verlander, Hou | 15 | 3 | 130.0 | 88 | 23 | 127 | 1.73 |
| Cease, ChW | 12 | 4 | 122.2 | 89 | 53 | 166 | 1.98 |
| McClanahan, TB | 10 | 4 | 122.0 | 78 | 23 | 158 | 2.07 |
| Manoah, Tor | 12 | 5 | 132.0 | 101 | 30 | 119 | 2.45 |
| Pérez, Tex | 9 | 2 | 131.0 | 114 | 38 | 116 | 2.47 |
| Cortes, NYY | 9 | 3 | 112.0 | 86 | 28 | 115 | 2.57 |
| Valdez, Hou | 10 | 4 | 135.0 | 107 | 48 | 120 | 2.87 |
| Irvin, Oak | 6 | 8 | 115.1 | 99 | 23 | 78 | 3.04 |
| Gausman, Tor | 8 | 8 | 111.2 | 119 | 20 | 132 | 3.06 |
| Gilbert, Sea | 10 | 4 | 128.1 | 116 | 36 | 120 | 3.09 |
| McKenzie, Cle | 7 | 8 | 120.0 | 88 | 32 | 113 | 3.38 |
| Bieber, Cle | 6 | 6 | 124.2 | 111 | 28 | 126 | 3.39 |
| Skubal, Det | 7 | 8 | 117.2 | 104 | 32 | 117 | 3.52 |
| Cole, NYY | 9 | 4 | 131.1 | 104 | 33 | 170 | 3.56 |
| Urquidy, Hou | 10 | 4 | 114.1 | 108 | 24 | 90 | 3.62 |
| Montgomery, NYY | 3 | 3 | 114.2 | 103 | 23 | 97 | 3.69 |
| Flexen, Sea | 7 | 8 | 111.0 | 111 | 41 | 76 | 3.73 |
| Gonzales, Sea | 6 | 11 | 118.1 | 125 | 39 | 65 | 3.95 |
| Ray, Sea | 8 | 8 | 129.2 | 110 | 44 | 149 | 3.96 |
| Taillon, NYY | 10 | 2 | 113.2 | 111 | 21 | 98 | 3.96 |
| Kluber, TB | 7 | 6 | 111.0 | 112 | 16 | 99 | 4.05 |
| Quantrill, Cle | 7 | 5 | 117.0 | 120 | 34 | 75 | 4.08 |
| Blackburn, Oak | 7 | 6 | 111.1 | 110 | 30 | 89 | 4.28 |
| Dunning, Tex | 1 | 6 | 106.2 | 110 | 43 | 93 | 4.30 |
| Lyles, Bal | 8 | 8 | 124.2 | 137 | 41 | 104 | 4.40 |
| Plesac, Cle | 2 | 10 | 108.1 | 113 | 33 | 83 | 4.49 |
| Pivetta, Bos | 8 | 8 | 123.2 | 120 | 45 | 119 | 4.51 |
| Keller, KC | 5 | 12 | 113.1 | 115 | 41 | 76 | 4.61 |
| Berríos, Tor | 8 | 4 | 118.0 | 130 | 29 | 107 | 5.19 |
